ADAMTS12

From Wikidraft
Jump to: navigation, search
edit
Template:PBB/81792

A disintegrin and metalloproteinase with thrombospondin motifs 12 is an enzyme that in humans is encoded by the ADAMTS12 gene.[1][2]

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS-1) motif. Individual members of this family differ in the number of C-terminal TS-1 motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains eight TS-1 motifs. It may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion.[2]

References

  1. Cal S, Arguelles JM, Fernandez PL, Lopez-Otin C (May 2001). "Identification, characterization, and intracellular processing of ADAM-TS12, a novel human disintegrin with a complex structural organization involving multiple thrombospondin-1 repeats". J Biol Chem 276 (21): 17932–40. doi:10.1074/jbc.M100534200. PMID 11279086. 
  2. 2.0 2.1 "Entrez Gene: ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=81792. 

Further reading

External Links

  • The MEROPS online database for peptidases and their inhibitors: M12.237

Template:Gene-5-stub Template:Metalloproteinases