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A disintegrin and metalloproteinase with thrombospondin motifs 12 is an enzyme that in humans is encoded by the ADAMTS12 gene.[1][2]

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS-1) motif. Individual members of this family differ in the number of C-terminal TS-1 motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains eight TS-1 motifs. It may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion.[2]


  1. Cal S, Arguelles JM, Fernandez PL, Lopez-Otin C (May 2001). "Identification, characterization, and intracellular processing of ADAM-TS12, a novel human disintegrin with a complex structural organization involving multiple thrombospondin-1 repeats". J Biol Chem 276 (21): 17932–40. doi:10.1074/jbc.M100534200. PMID 11279086. 
  2. 2.0 2.1 "Entrez Gene: ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12". 

Further reading[edit]

External Links[edit]

  • The MEROPS online database for peptidases and their inhibitors: M12.237

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