Mendelian Inheritance in Man

Template:Primarysources The Mendelian Inheritance in Man project is a Wikipedia:database that catalogues all the known Wikipedia:diseases with a genetic component, and—when possible—links them to the relevant Wikipedia:genes in the Wikipedia:human genome and provides references for further research and tools for genomic analysis of a catalogued gene.

Versions

It is available as a book named after the project, and it is currently in its 12th edition. The Wikipedia:online version is called Online Mendelian Inheritance in Man (OMIM), which can be accessed with the Wikipedia:Entrez database searcher of the Wikipedia:National Library of Medicine and is part of the NCBI Education project.

Collection process

The information in this Wikipedia:database was collected and processed under the leadership of Dr. Wikipedia:Victor A. McKusick at Wikipedia:Johns Hopkins University, assisted by a team of Wikipedia:science writers and editors. Relevant articles are identified, discussed and written up in the relevant entries in the MIM database.

The MIM code

Every disease and Wikipedia:gene is assigned a six digit number of which the first number classifies the method of inheritance.

If the initial digit is 1, the trait is deemed Wikipedia:autosomal dominant; if 2, Wikipedia:autosomal recessive; if 3, Wikipedia:X-linked. Wherever a trait defined in this dictionary has a MIM number, the number from the 12th edition of MIM, is given in square brackets with or without an asterisk (asterisks indicate that the mode of inheritance is known; a number symbol (#) before an entry number means that the phenotype can be caused by mutation in any of two or more genes) as appropriate e.g., Wikipedia:Pelizaeus-Merzbacher disease [MIM*169500] is a well-established, autosomal, dominant, mendelian disorder.

First Digit	Range of MIM codes	Method of inheritance
1	100000–199999	Wikipedia:Autosomal dominant loci or Wikipedia:phenotypes (created before May 15, 1994)
2	200000–299999	Wikipedia:Autosomal recessive loci or Wikipedia:phenotypes (created before May 15, 1994)
3	300000–399999	Wikipedia:X-linked loci or Wikipedia:phenotypes
4	400000–499999	Wikipedia:Y-linked loci or Wikipedia:phenotypes
5	500000–599999	Wikipedia:Mitochondrial loci or Wikipedia:phenotypes
6	600000–	Wikipedia:Autosomal loci or Wikipedia:phenotypes (created after May 15, 1994)

See also

• Wikipedia:Medical classification
• Wikipedia:Online Mendelian Inheritance in Animals
• Wikipedia:Mendelian inheritance
• Wikipedia:Comparative Toxicogenomics Database, a database that integrates chemicals and genes with human diseases, including OMIM data.
• Wikipedia:DECIPHER, a database of chromosomal imbalance and associated phenotype in humans, using Wikipedia:Ensembl resources.

References

• Table from the OMIM FAQ
• Template:Cite book
• Hamosh, A, Scott, AF, Amberger, JS, Bocchini, CA, McKusick, VA. (2005) Online Mendelian inheritance in man (OMIM), a knowledgebase of human genes and genetic disorders. Nucleic Acids Research 33, D514-D517

External links

• Online Mendelian Inheritance in Man (to search OMIM)