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NEDD4-like E3 ubiquitin-protein ligase WWP2 is an enzyme that in humans is encoded by the WWP2 gene.[1][2][3]

This gene encodes a member of the NEDD4-like protein family. The family of proteins is known to possess ubiquitin-protein ligase activity. The encoded protein contains 4 tandem WW domains. The WW domain is a protein motif consisting of 35 to 40 amino acids and is characterized by 4 conserved aromatic residues. The WW domain may mediate specific protein-protein interactions. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[3]


WWP2 has been shown to interact with SCNN1B[2][4] and ATN1.[5]


  1. Pirozzi G, McConnell SJ, Uveges AJ, Carter JM, Sparks AB, Kay BK, Fowlkes DM (Jun 1997). "Identification of novel human WW domain-containing proteins by cloning of ligand targets". J Biol Chem 272 (23): 14611–6. doi:10.1074/jbc.272.23.14611. PMID 9169421. 
  2. 2.0 2.1 McDonald FJ, Western AH, McNeil JD, Thomas BC, Olson DR, Snyder PM (Aug 2002). "Ubiquitin-protein ligase WWP2 binds to and downregulates the epithelial Na(+) channel". Am J Physiol Renal Physiol 283 (3): F431–6. doi:10.1152/ajprenal.00080.2002. PMID 12167593. 
  3. 3.0 3.1 "Entrez Gene: WWP2 WW domain containing E3 ubiquitin protein ligase 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11060. 
  4. Harvey, K F; Dinudom A, Cook D I, Kumar S (Mar. 2001). "The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel". J. Biol. Chem. (United States) 276 (11): 8597–601. doi:10.1074/jbc.C000906200. ISSN 0021-9258. PMID 11244092. 
  5. Wood, J D; Yuan J, Margolis R L, Colomer V, Duan K, Kushi J, Kaminsky Z, Kleiderlein J J, Sharp A H, Ross C A (Jun. 1998). "Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins". Mol. Cell. Neurosci. (UNITED STATES) 11 (3): 149–60. doi:10.1006/mcne.1998.0677. ISSN 1044-7431. PMID 9647693. 

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